ARHGAP36

Rho GTPase activating protein 36

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000147256
UniProt:
Q6ZRI8
OMIM:
300937
Synonyms:
FLJ30058

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cytosol

References: PMID:30598432

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Patched1-ArhGAP36-PKA- Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation(30598432).