ARL15

ARF like GTPase 15

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000185305
UniProt:
Q9NXU5
Synonyms:
ARFRP2, FLJ20051

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.49) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, herniated abdomil wall

Subcellular localization

cilia, basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

ARL15 has localized to cilia.