ARL16

Cilia effects upon perturbation of ARL16

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.04) PMID:29459680
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=215, lfc=-2.49) PMID:30270045

Phenotypes

Mouse phenotype:

abnormal skin morphology, small spleen, abnormal digit morphology, abnormal spleen morphology, decreased body weight, polysyndactyly, abnormal eye morphology, enlarged thymus, abnormal thymus morphology, abnormal skeletal muscle morphology

Subcellular localization

cilia, basal body

References: PMID:41005307

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

ARL16 has localized in cilia.