ARL16

Cilia effects upon perturbation of ARL16

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.04) PMID:29459680
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=215, lfc=-2.49) PMID:30270045

Phenotypes

Mouse phenotype:

abnormal skin morphology, small spleen, abnormal digit morphology, abnormal spleen morphology, decreased body weight, polysyndactyly, abnormal eye morphology, enlarged thymus, abnormal thymus morphology, abnormal skeletal muscle morphology

Mouse ciliopathy phenotype:

abnormal testis morphology, enlarged heart, small testis, abnormal heart morphology

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

ARL16 has localized in cilia.

Model organism evidence