ARL2
ARF like GTPase 2
- Ensembl:
- ENSG00000213465
- UniProt:
- P36404
- OMIM:
- 601175
- Synonyms:
- ARFL2
Cilia effects upon perturbation of ARL2
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
- Overexpression effect:
- Shorter cilia
Ciliogenesis screen results (4 screens)
- Kim2016: No effect
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Ciliopathy associations
- Retinal Dystrophy/Degeneration
Subcellular localization
centrosome, cilia, mitochondria, nucleus
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Metabolism
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Regulates cilia stability and development of outer segments in rod photoreceptor neurons(30446707).
Model organism evidence
Mus musculus (3 references)
To evaluate this function in the retina, we conditionally deleted ARL2 in mouse retina at two distinct stages, either during the embryonic development (retArl2-/-) or after ciliogenesis specifically in rods (rodArl2-/-).
Roles for ELMOD2 and Rootletin in ciliogenesis.