ARL2

ARF like GTPase 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000213465
UniProt:
P36404
OMIM:
601175
Synonyms:
ARFL2

Cilia effects upon perturbation of ARL2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia
Overexpression effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Retinal Dystrophy/Degeneration

References: PMID:30945270

Subcellular localization

centrosome, cilia, mitochondria, nucleus, basal body

References: PMID:41005307, PMID:30446707

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Regulates cilia stability and development of outer segments in rod photoreceptor neurons(30446707).