ARMC3

armadillo repeat containing 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000165309
UniProt:
Q5W041
OMIM:
611226
Synonyms:
CT81, FLJ32827, VAC8

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating cholesterol level

Subcellular localization

cilia, axoneme, central apparatus

References: doi:10.7554/eLife.110601, PMID:41410385, PMID:42010243, PMID:32616903

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

ARMC3, EFCAB6, FAM183A, MYCBPAP, RIBC2 and VWA3A, associated with motile cilia ( 32616903). Confirmed to localize to the axonemal central lumen as a constitutive component of the C2a projection; its ciliary localization depends on the other C2a proteins (Lyu et al. 2026, eLife, DOI 10.7554/eLife.110601).