ARMC3

armadillo repeat containing 3

Ensembl:
ENSG00000165309
UniProt:
Q5W041
OMIM:
611226
Synonyms:
CT81, FLJ32827, VAC8

Cilia effects upon perturbation of ARMC3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating cholesterol level
Mouse ciliopathy phenotype:
male infertility

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

ARMC3, EFCAB6, FAM183A, MYCBPAP, RIBC2 and VWA3A, associated with motile cilia ( 32616903).