ASNS

asparagine synthetase (glutamine-hydrolyzing)

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000070669
UniProt:: P08243
OMIM:: 108370

Cilia effects upon perturbation of ASNS

Loss-of-function effect:: Longer cilia

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.75) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.97) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal reti pigmentation, abnormal glucose homeostasis, decreased hemoglobin content

Subcellular localization

basal body, cytosol

References: PMID:36879119

Functional category

Ciliary assembly/disassembly

Function

Ift88-mutant cells lacking cilia show reduced glutamine-dependent mitochondrial a plerosis during metabolic stress, due to reduced expression and activity of ASNS at the base of cilia (36879119). Silencing Asns induced the expected elongation of cilia at baseline(PMID: 36879119).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.