ASNS

asparagine synthetase (glutamine-hydrolyzing)

Ensembl:
ENSG00000070669
UniProt:
P08243
OMIM:
108370

Cilia effects upon perturbation of ASNS

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.75) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.97) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal reti pigmentation, abnormal glucose homeostasis, decreased hemoglobin content
Mouse ciliopathy phenotype:
increased heart weight

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • T cell biology

Function

Ift88-mutant cells lacking cilia show reduced glutamine-dependent mitochondrial a plerosis during metabolic stress, due to reduced expression and activity of ASNS at the base of cilia (36879119). Silencing Asns induced the expected elongation of cilia at baseline(PMID: 36879119).