ATAT1

alpha tubulin acetyltransferase 1

Ensembl:
ENSG00000231257, ENSG00000206488, ENSG00000229061, ENSG00000223752, ENSG00000234549, ENSG00000235658, ENSG00000137343
UniProt:
Q5SQI0
OMIM:
615556
Synonyms:
C6ORF134, EM:AB023049.7, FLJ13158, MEC17

Cilia effects upon perturbation of ATAT1

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.58) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation(21068373).

Model organism evidence

Mus musculus (1 reference)

We observed ATAT1 in the cytoplasm of round spermatids, the flagella of elongated spermatids, and in the cytoplasm of step 16 spermatids, just before its release into the lumen.

PMIDs: 33390366