ATAT1
alpha tubulin acetyltransferase 1
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000231257
- UniProt:
- Q5SQI0
- OMIM:
- 615556
- Synonyms:
- C6ORF134, EM:AB023049.7, FLJ13158, MEC17
Cilia effects upon perturbation of ATAT1
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- No effect
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.58) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Subcellular localization
cilia, microtubules
References: PMID:21068373
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Signaling (Hedgehog, GPCRs, ion channels)
Function
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation(21068373).