ATF3

activating transcription factor 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000162772
UniProt:
P18847
OMIM:
603148

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.51) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.36, ciliated=55.7%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.48) PMID:41160700

Phenotypes

Mouse phenotype:
decreased locomotor activity

Subcellular localization

basal body, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Cardiac & muscle development
  • Transcription regulation

Function

ATF3 has localized in basal body.