ATG3

autophagy related 3

Ensembl:
ENSG00000144848
UniProt:
Q9NT62
OMIM:
609606
Synonyms:
APG3L, DKFZP564M1178, FLJ22125, MGC15201, PC3-96

Cilia effects upon perturbation of ATG3

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body, cilia, cytosol

Functional category

  • Ciliary assembly/disassembly

Function

OFD1 at the centriolar satellites is rapidly degraded by autophagy upon serum starvation. In autophagy- deficient Atg5 or Atg3 null mouse embryonic fibroblasts, OFD1 accumulates at centriolar satellites, leading to fewer and shorter primary cilia and a defective recruitment of BBS4 (Bardet-Biedl syndrome 4) to cilia. Atg3 null mouse embryonic fibroblasts, Ofd1 accumulates at centriolar satellites, leading to fewer and shorter primary cilia(PMID: 24089205).

Model organism evidence

Mus musculus (1 reference)

In autophagy-deficient Atg5 or Atg3 null mouse embryonic fibroblasts, OFD1 accumulates at centriolar satellites, leading to fewer and shorter primary cilia and a defective recruitment of BBS4 (Bardet-Biedl syndrome 4) to cilia.

PMIDs: 24089205