ATG5

autophagy related 5

Ensembl:
ENSG00000057663
UniProt:
Q9H1Y0
OMIM:
604261
Synonyms:
APG5, APG5L, ASP, HAPG5

Cilia effects upon perturbation of ATG5

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.32) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

OFD1 at the centriolar satellites is rapidly degraded by autophagy upon serum starvation. In autophagy- deficient Atg5 or Atg3 null mouse embryonic fibroblasts, OFD1 accumulates at centriolar satellites, leading to fewer and shorter primary cilia and a defective recruitment of BBS4 (Bardet-Biedl syndrome 4) to cilia. MUtations cause spinocerebellar ataxia 25.The percentage of Atg5−/− cells that form a primary cilium, as compared to Atg5+/+ cells, was significantly reduced and the cilia that did form were shorter (PMID: 24089205).