ATMIN

ATM interactor

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000291953
UniProt:: O43313
OMIM:: 614693
Synonyms:: ASCIZ, KIAA0431, ZNF822

Cilia effects upon perturbation of ATMIN

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.27) PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=795, lfc=-1.92) PMID:30270045

Subcellular localization

nucleus

References: PMID:25294941

Functional category

Ciliary assembly/disassembly

Function

Regulates ciliogenesis. Interacts with DYNLL1 ( 25294941). Knockdown of Atmin or Dynll1 in cultured cells resulted in almost identical phenotypes, fewer ciliated cells and reduced ciliary length(PMID: 25294941).

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