ATOH1

atonal bHLH transcription factor 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000172238
UniProt:
Q92858
OMIM:
601461
Synonyms:
BHLHA14, HATH1, MATH-1, MATH1

Cilia effects upon perturbation of ATOH1

Cilia number / % ciliated:
Increased Cilia Number/Decreased cilia number

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.51) PMID:41160700

Subcellular localization

nucleus

References: PMID:30695697

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth
  • Transcription regulation

Function

Controls Primary Cilia Formation to Allow for SHH- Triggered Granule Neuron Progenitor Proliferation. Atoh1-knockdown GNPs were less likely to display a primary cilium compared to control (PMID: 30695697). Morphological examinations revealed that the numbers of stereocilia bundles of both IHCs and OHCs in the Atoh1-treated animals were significantly greater than those of the untreated cochleae (https://doi.org/10.1371/journal.pone.0046355).