ATP1A4

ATPase Na+/K+ transporting subunit alpha 4

Ensembl:: ENSG00000132681
UniProt:: Q13733
OMIM:: 607321
Synonyms:: ATP1AL2

Cilia effects upon perturbation of ATP1A4

Ciliogenesis screen results (3 screens)

Kim2016: Not Reported
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse ciliopathy phenotype:: male infertility

Subcellular localization

flagella

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Metabolism
T cell biology
Reproduction & sperm
Viral interactions
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)

Function

Rat Atp1a4 transgene is expressed in mouse spermatozoa and that it is localized to the sperm flagellum(20826726).

Model organism evidence

Mus musculus (2 references)

Na,K-ATPase Atp1a4 isoform is important for maintaining sperm flagellar shape.

We showed that the rat Atp1a4 transgene is expressed in mouse spermatozoa and that it is localized to the sperm flagellum.

PMIDs: 33977467, 20826726

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