ATP2A2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Ensembl:
ENSG00000174437
UniProt:
P16615
OMIM:
108740
Synonyms:
ATP2B, DAR, SERCA2

Cilia effects upon perturbation of ATP2A2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.60) PMID:41160700

Phenotypes

Mouse phenotype:
decreased mean platelet volume, decreased circulating alkaline phosphatase level, preweaning lethality, complete penetrance, increased fasting circulating glucose level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

ATP2A2 has localized in primary cilia.