ATP2B4

ATPase plasma membrane Ca2+ transporting 4

Ensembl:
ENSG00000058668
UniProt:
P23634
OMIM:
108732
Synonyms:
ATP2B2, MXRA1, PMCA4

Cilia effects upon perturbation of ATP2B4

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

When immunostaining of sperm was performed using a PMCA4-specific monoclo l antibody, Pmca4+/+ sperm exhibited intense fluorescence in the principal piece of the sperm tail and faint staining in the interior of the mid-piece (15178683).