ATP4A

ATPase H+/K+ transporting subunit alpha

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000105675
UniProt:
P20648
OMIM:
137216
Synonyms:
ATP6A

Cilia effects upon perturbation of ATP4A

Cilia number / % ciliated:
Incrased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.83) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:10764766

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ATP4a and canonical Wnt signaling are required in the epidermis for expression of foxj1, a transcriptional regulator of motile ciliogenesis. Stomachs of adult Atp4a⁻/⁻ mice exhibited metaplasia, which included the presence of ciliated cells (https://doi.org/10.1074/jbc.M001558200)