ATP4A
ATPase H+/K+ transporting subunit alpha
- Ensembl:
- ENSG00000105675
- UniProt:
- P20648
- OMIM:
- 137216
- Synonyms:
- ATP6A
Cilia effects upon perturbation of ATP4A
- Cilia number / % ciliated:
- Incrased cilia number
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.83) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Metabolism
- Signaling (Hedgehog, GPCRs, ion channels)
Function
ATP4a and canonical Wnt sig ling are required in the epidermis for expression of foxj1, a transcriptio l regulator of motile ciliogenesis. Stomachs of adult Atp4a⁻/⁻ mice exhibited metaplasia, which included the presence of ciliated cells (https://doi.org/10.1074/jbc.M001558200)
Model organism evidence
Xenopus (3 references)
We found that in the floor plate of the neural tube ATP4a-dependent canonical Wnt signaling was required for foxj1 expression, downstream of or in parallel to Hedgehog signaling.
ATP4a and canonical Wnt signaling were required in the epidermis for expression of foxj1, a transcriptional regulator of motile ciliogenesis.