ATP8A2

ATPase phospholipid transporting 8A2

Ensembl:
ENSG00000132932
UniProt:
Q9NTI2
OMIM:
605870
Synonyms:
ATPIB, ML-1

Cilia effects upon perturbation of ATP8A2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.35) PMID:41160700

Phenotypes

Mouse phenotype:
increased circulating glucose level
Human ciliopathy phenotype:
Rare hereditary ataxia

Subcellular localization

flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

ATP8A2 has localized in flagella.