AURKA
aurora kinase A
- Ensembl:
- ENSG00000087586
- UniProt:
- O14965
- OMIM:
- 603072
- Synonyms:
- AIK, ARK1, AURA, BTAK, PPP1R47
Cilia effects upon perturbation of AURKA
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- No effect
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.91) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.82) PMID:41160700
Phenotypes
- Mouse phenotype:
- sclerocornea, embryonic lethality prior to organogenesis, preweaning lethality, complete penetrance, increased grip strength, embryonic lethality prior to tooth bud stage, decreased leukocyte cell number, abnormal bone structure
Subcellular localization
basal body, centrosome, cytosol, microtubules, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Reproduction & sperm
- Protein processing & maturation
Function
Kinase at the basal body of cilia. Phosphorylates HDAC6 to promote cilia disassembly(PMID: 17604723).