AURKA

aurora kinase A

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000087586
UniProt:
O14965
OMIM:
603072
Synonyms:
AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7

Cilia effects upon perturbation of AURKA

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
No effect

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.91) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.82) PMID:41160700

Phenotypes

Mouse phenotype:
sclerocornea, embryonic lethality prior to organogenesis, preweaning lethality, complete penetrance, increased grip strength, embryonic lethality prior to tooth bud stage, decreased leukocyte cell number, abnormal bone structure

Subcellular localization

basal body, centrosome, cytosol, microtubules, nucleus

References: PMID:41005307, PMID:17604723

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation

Function

Kinase at the basal body of cilia. Phosphorylates HDAC6 to promote cilia disassembly(PMID: 17604723).