AVIL

Cilia effects upon perturbation of AVIL

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Unknown

Overexpression effect:

Unknown

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.68) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=4.16) PMID:20393562

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

Among the ciliogenesis modulators with high confirmation screen scores (Supplementary Table 2) are two Gelsolin (GSN) family proteins GSN and AVIL, which regulate cytoskeletal actin organization by severing actin filaments11. Depletion of GSN proteins by two independent siRNAs significantly reduced ciliated cell numbers, suggesting that actin filament severing is involved in ciliogenesis (20393563).