AXDND1

axonemal dynein light chain domain containing 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000162779
UniProt:
Q5T1B0
Synonyms:
C1ORF125, FLJ32940

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.67) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal vibrissa morphology

Subcellular localization

basal body, cilia, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm
  • Transition zone

Function

AXDND1 has localized in basal body, transition zone, ciliary tip, primary cilia.