B4GAT1

beta-1,4-glucuronyltransferase 1

Ensembl:
ENSG00000174684
UniProt:
O43505
OMIM:
605517
Synonyms:
B3GN-T1, B3GNT1, B3GNT6, BETA3GNTI, IGAT

Cilia effects upon perturbation of B4GAT1

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Axon guidance & growth

Function

Involvement of BGNT-1.1(BGNT-1.1 is the orthologue of human B3GNT1/B4GAT1) in ciliated sensory neuron function and morphogenesis. BGNT-1.1 functions at the trans-Golgi network of sheath cells (glia) to influence dye-filling and cilium length, in a cell non-autonomous manner ( 27508411). Specifically, bgnt-1.1 mutants were observed to have significantly longer cilia compared to wild-type worms(PMID: 27508411).

Model organism evidence

Mus musculus (1 reference)

Brn-3b is highly expressed in mature spermatids and infertility in constitutive male Brn-3b knockout (KO) mice is characterised by structural and functional testicular changes such as reduced sperm counts, impaired motility and ultrastructural defects including disrupted acrosomes and defects in

PMIDs: 41282076