B4GAT1

beta-1,4-glucuronyltransferase 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000174684
UniProt:: O43505
OMIM:: 605517
Synonyms:: B3GN-T1, B3GNT1, B3GNT6, BETA3GNTI, IGAT, IGNT

Cilia effects upon perturbation of B4GAT1

Loss-of-function effect:: Longer cilia

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:27508411

Functional category

Ciliary assembly/disassembly
Neurogenesis & migration
Axon guidance & growth

Function

Involvement of BGNT-1.1(BGNT-1.1 is the orthologue of human B3GNT1/B4GAT1) in ciliated sensory neuron function and morphogenesis. BGNT-1.1 functions at the trans-Golgi network of sheath cells (glia) to influence dye-filling and cilium length, in a cell non-autonomous manner ( 27508411). Specifically, bgnt-1.1 mutants were observed to have significantly longer cilia compared to wild-type worms(PMID: 27508411).

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