BANF2

BANF family member 2

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000125888
Synonyms:
BAF-L, BAF2, BAFL, C20ORF179, DJ803K15.1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Male Infertility

References: PMID:35207567

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:41459802

Functional category

  • Non-motile cilium / primary cilium

Function

Since BAF-L can heterodimerize with BAF in vitro, we investigated how the absence of BAF-L affected BAF localisation in Banf2-/-, Nup210l-/- spermatids by immunofluorescence. In control mice, BAF exhibits cytoplasmic and nucleoplasmic localization in step 1-3 round spermatids. BAF becomes exclusively nucleoplasmic in spermatids from step 4-5, concentrated at a point on the nuclear periphery at the posterior pole, where the distal centriole and the flagellar axoneme contact the nucleus(PMID: 41459802).