BDNF

brain derived neurotrophic factor

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000176697
UniProt:
P23560
OMIM:
113505

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.61) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
obesity

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:24867303

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Axon guidance & growth
  • Transcription regulation

Function

TrkB is localized to the axonemes or basal bodies of cilia only in the presence of BDNF ( 24867303).