BEST2

bestrophin 2

Ensembl:
ENSG00000039987
UniProt:
Q8NFU1
OMIM:
607335
Synonyms:
FLJ20132, VMD2L1

Cilia effects upon perturbation of BEST2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance, cornea deposits

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

The Bestrophin channel 2, Best2, was also detected in mouse cilia and ClCa4l, belonging to the ClCa family of Ca(2+)-activated Cl(-) channels, were found in rat cilia (27113933).