BFAR

bifunctional apoptosis regulator

Ensembl:: ENSG00000103429
UniProt:: Q9NZS9
OMIM:: 619516
Synonyms:: BAR, RNF47

Cilia effects upon perturbation of BFAR

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.10) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.9) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.35, ciliated=55.6%) PMID:26595381

Subcellular localization

cilia

Function

The collection of regulators has diverse distributions throughout the cell with Bfar, Cop1, Cul9, Fancg, Skp1a, Uba3, Ube2l3, and Wwp1 showing weak localization to cilia. In addition, Sytl4 localized to the ciliary pocket at the base of the cilium, and Fbxw11 localized to centriolar satellites Positive regulator of Hedgehog signaling (PMID: 34161574).

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