BICD2

BICD cargo adaptor 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000185963
UniProt:: Q8TD16
OMIM:: 609797
Synonyms:: KIAA0699

Cilia effects upon perturbation of BICD2

Cilia number / % ciliated:: Increased Cilia Number/Decreased cilia number

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.14, ciliated=21.3%) PMID:26595381

Subcellular localization

basal body

References: PMID:38526325

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

BICD2 mainly localizes to the Golgi complex and has properties of a peripheral coat protein, yet it also co-localizes with dynactin at microtubule plus ends and BICD2 plays a role in the dynein- dynactin interaction on the surface of membranous organelles (11483508). BICD2 specifically concentrated around centrosomes at the base of cilia(24614806). BICD2 depletion leads to a significant reduction in ciliation overexpressing BICD2, revealing a significant promotion of ciliogenesis (PMID: 38526325)

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