BICD2

Cilia effects upon perturbation of BICD2

Cilia number / % ciliated:

Increased Cilia Number/Decreased cilia number

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.14, ciliated=21.3%) PMID:26595381

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation

Function

BICD2 mainly localizes to the Golgi complex and has properties of a peripheral coat protein, yet it also co-localizes with dy ctin at microtubule plus ends and BICD2 plays a role in the dynein- dy ctin interaction on the surface of membranous organelles (11483508). BICD2 specifically concentrated around centrosomes at the base of cilia(24614806). BICD2 depletion leads to a significant reduction in ciliation overexpressing BICD2, revealing a significant promotion of ciliogenesis (PMID: 38526325)

Model organism evidence