BMP2
bone morphogenetic protein 2
- Ensembl:
- ENSG00000125845
- UniProt:
- P12643
- OMIM:
- 112261
- Synonyms:
- BMP2A
Cilia effects upon perturbation of BMP2
- Cilia number / % ciliated:
- Decreased cilia number
- Overexpression effect:
- No Effect
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Human ciliopathy phenotype:
- short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1; short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies
Subcellular localization
cilia, transition zone
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Neurogenesis & migration
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transition zone
- ECM & connective tissue
- Transcription regulation
- Cilia length regulation
Function
BMP2 has localized in transition zone, primary cilia. Overexpression of BMP2 by transfection partially rescued the differentiation of IFT80d/d DPSCs (Fig. S4A and S4B). However, BMP2 did not change the cilia length and ciliated cell population (doi:10.7150/ijbs.27231). Supplementation of BMP2 or BMP4 in culture media significantly reduced the number of cells with multiple cilia among the total cells (DOI:10.1620/tjem.252.199).