BMPR2

bone morphogenetic protein receptor type 2

Ensembl:
ENSG00000204217
UniProt:
Q13873
OMIM:
600799
Synonyms:
BMPR-II, BMPR3, BRK-3, PPH1, T-ALK

Cilia effects upon perturbation of BMPR2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.70) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.14) PMID:20393562

Phenotypes

Human ciliopathy phenotype:
Pulmonary arterial hypertension associated with congenital heart disease

Subcellular localization

cilia associated gene, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Axon guidance & growth
  • ECM & connective tissue
  • Transcription regulation

Function

BMP sig ling component, including upregulated gene Bmpr2 , consistently responded to strain, while Cox2 and Ift88 showed differential regulation depending on strain intensity. BMPR2 knockdown cells had significantly fewer cilia formation than the control cells, BMPR2 knockdown cells had longer cilia when cilia were ever formed (https://doi.org/10.1002/advs.201903140).

Model organism evidence

C. elegans (1 reference)

Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8).

PMIDs: 37099601

Mus musculus (1 reference)

Endothelial β-arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia.

PMIDs: 36532314