BRAF

B-Raf proto-oncogene, serine/threonine kinase

Ensembl:
ENSG00000157764
UniProt:
P15056
OMIM:
164757
Synonyms:
BRAF-1, BRAF1

Cilia effects upon perturbation of BRAF

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
renal cell carcinoma

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia(25412847).