BRCA1

BRCA1 DNA repair associated

Ensembl:: ENSG00000012048
UniProt:: P38398
OMIM:: 113705
Synonyms:: BRCC1, FANCS, PPP1R53, RNF53

Cilia effects upon perturbation of BRCA1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.38) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.27, ciliated=55.0%) PMID:26595381

Subcellular localization

basal body, microtubules, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

N-termi l region of BRCA1, and γ-tubulin, associated with BARD1, and localized the centrosomes throughout the cell cycle., RACK1 is required for the proper centrosomal localization of BRCA1 (30617304).

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