BTG4

BTG anti-proliferation factor 4

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000137707
OMIM:: 605673
Synonyms:: APRO3, PC3B

Subcellular localization

Endoplasmic reticulum, Golgi apparatus

References: PMID:37102425

Functional category

Metabolism
Ciliary assembly/disassembly
Cilia–cytoskeleton/adhesion links

Function

We characterized the expression of BTG4, LAYN, and HOATZ, located in the MIR34B/C locus using single-cell RNA-seq and super-resolution microscopy from human, mouse, or pig multiciliogenesis models. BTG4, LAYN, and HOATZ transcripts were expressed in both precursors and mature MCCs. The Layilin/LAYN protein was absent from primary cilia, but it was expressed in apical membrane regions or throughout motile cilia. LAYN silencing altered apical actin cap formation and multiciliogenesis. HOATZ protein was detected in primary cilia or throughout motile cilia. Altogether, our data suggest that the MIR34B/C locus may gather potential actors of multiciliogenesis(37102425).

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