BUB1

BUB1 mitotic checkpoint serine/threonine kinase

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000169679
UniProt:: O43683
OMIM:: 602452
Synonyms:: BUB1A, BUB1L, HBUB1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.03) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: embryonic lethality prior to organogenesis, preweaning lethality, complete penetrance

Subcellular localization

cytosol, nucleus

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

BioID2-tagged BUB1, BUB3, BUBR1, MAD1L1, and MAD2L1 localized to kinetochores, overlapping fluorescence signal with anticentromere antibodies (ACA) during prometaphase. BUB1 kinase activity was important for its proper localization to kinetochores and for the localization of the Astrin–Ki strin minor complex components PLK1 and SGO2 to the kinetochore ( 34087075). The Astrin–Ki strin complex is important for aligning and attaching to kinetochores(34087075).

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