BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

Ensembl:
ENSG00000156970
UniProt:
O60566
OMIM:
602860
Synonyms:
BUB1A, BUBR1, MAD3L, SSK1

Cilia effects upon perturbation of BUB1B

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.03) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

BUB1B has localized in basal body. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates (PMID: 21389084)