C3AR1

complement C3a receptor 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000171860
UniProt:: Q16581
OMIM:: 605246
Synonyms:: AZ3B, C3AR

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.14) PMID:41160700

Ciliopathy associations

Retinal Dystrophy/Degeneration

References: PMID:36110094

Subcellular localization

No ciliary localization reported (cilia-associated gene).

Functional category

Small GTPases; Signaling (Hedgehog, GPCRs, ion channels)

Function

The expression of C3 and C3a receptor (C3ar1) is positively associated with the inflammatory response and retinal degeneration. Genetic deletion of C3 and pharmacological inhibition of C3ar1 resulted in the alleviation of neuroinflammation, prevention of photoreceptor cell apoptosis and restoration of visual function(PMID: 36110094).

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