C3AR1

complement C3a receptor 1

Ensembl:
ENSG00000171860
UniProt:
Q16581
OMIM:
605246
Synonyms:
AZ3B, C3AR

Cilia effects upon perturbation of C3AR1

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.14) PMID:41160700

Phenotypes

Mouse ciliopathy phenotype:
polycystic kidney; abnormal kidney morphology

Ciliopathy associations

  • Retinal Dystrophy/Degeneration

Subcellular localization

cilia associated gene

Functional category

  • Small GTPases; Signaling (Hedgehog, GPCRs, ion channels)

Function

The expression of C3 and C3a receptor (C3ar1) is positively associated with the inflammatory response and retinal degeneration. Genetic deletion of C3 and pharmacological inhibition of C3ar1 resulted in the alleviation of neuroinflammation, prevention of photoreceptor cell apoptosis and restoration of visual function(PMID: 36110094).