CABYR
calcium binding tyrosine phosphorylation regulated
- Ensembl:
- ENSG00000154040
- UniProt:
- O75952
- OMIM:
- 612135
- Synonyms:
- CBP86, CT88, FSP-2
Cilia effects upon perturbation of CABYR
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.48) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.02) PMID:41160700
Subcellular localization
flagella, nucleus
Functional category
- Actin & cytoskeleton regulation
- Reproduction & sperm
- Protein processing & maturation
Function
The CABYR CR-A antibody localized to the entire length of the principal piece, and, unlike FSCB, CABYR also extended into the end piece (17855365).
Model organism evidence
Mus musculus (2 references)
ASP and ROPN1 are 41% identical in sequence, interact with a variety of AKAPs in a manner similar to PKA, and are expressed in ciliated and flagellated human cells.
CABYR protein gradually migrates into the sperm flagellum and localizes to the FS of the principal piece during steps 15-16.