CABYR

calcium binding tyrosine phosphorylation regulated

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000154040
UniProt:
O75952
OMIM:
612135
Synonyms:
CBP86, CT88, FSP-2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.48) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.02) PMID:41160700

Subcellular localization

flagella, nucleus

References: Human Protein Atlas, PMID:17855365

Functional category

  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation

Function

The CABYR CR-A antibody localized to the entire length of the principal piece, and, unlike FSCB, CABYR also extended into the end piece (17855365).