CACNA2D4

calcium voltage-gated channel auxiliary subunit alpha2delta 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000151062
UniProt:
Q7Z3S7
OMIM:
608171
Synonyms:
ALPHA2DELTA-4

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.22) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity

Subcellular localization

flagella, lysosomes

References: PMID:25613900

Functional category

  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CACNA2D4 has localized in flagella.