CALCA

calcitonin related polypeptide alpha

Ensembl:
ENSG00000110680
UniProt:
P01258
OMIM:
114130
Synonyms:
CALC1, CGRP, CGRP-ALPHA

Cilia effects upon perturbation of CALCA

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.50) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

The vertebrate/human-type vasoactive molecule adrenomedullin (ADM) and its close relative compounds (PAMP and CGRP) have ligand-specific, diverse effects on the migratory behaviour of the eukaryotic ciliate Tetrahyme piriformis ( 26481478).