CAMK2B

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.00) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased vertical activity, decreased prepulse inhibition, decreased thigmotaxis, decreased anxiety-related response, abnormal behavior, preweaning lethality, incomplete penetrance, hyperactivity

Human ciliopathy phenotype:

intellectual disability, autosomal dominant 54; Intellectual disability

Subcellular localization

cilia, Cytosol, Nucleus, ciliary tip, transition zone

References: PMID:41005307, PMID:20630945, PMID:23747599

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Neurogenesis & migration
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

Zebrafish CaMK-II is expressed in ciliated tissues including Kupffer's vesicle (PMID 20630945), kidney (PMID 21752935), neuromasts and inner ear, and its suppression alters ciliated hair-cell number and Delta-Notch signalling. The zebrafish work does not resolve which human CAMK2 paralog is responsible; no CAMK2B-specific ciliary localization has been curated.