CAMK2B

calcium/calmodulin dependent protein kinase II beta

Ensembl:
ENSG00000058404
UniProt:
Q13554
OMIM:
607707
Synonyms:
CAM2, CAMK2, CAMKB, CAMKIIB

Cilia effects upon perturbation of CAMK2B

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.00) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased vertical activity, decreased prepulse inhibition, decreased thigmotaxis, decreased anxiety-related response, abnormal behavior, preweaning lethality, incomplete penetrance, hyperactivity
Human ciliopathy phenotype:
intellectual disability, autosomal dominant 54; Intellectual disability

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

CaMK-II is expressed in ciliated tissues of the zebrafish embryo, including the Kupffer's Vesicle (KV)(20630945), kidney(21752935), neuromasts, and inner ear. CaMK-II suppression results in additio l ciliated hair cells and altered levels of Delta-Notch signalling members(9806913). CaMK-II plays a critical role in the developing ear, influencing cell differentiation through extranuclear effects on Delta-Notch signalling (23747599).

Model organism evidence

Mus musculus (1 reference)

Additionally, the ciliary localization of KIF17 is regulated by a C-terminal consensus sequence (KRKK) that is immediately adjacent to a conserved residue (mouse S1029/zebrafish S815) previously shown to be phosphorylated by CaMKII.

PMIDs: 30458707

Danio rerio (1 reference)

Additionally, the ciliary localization of KIF17 is regulated by a C-terminal consensus sequence (KRKK) that is immediately adjacent to a conserved residue (mouse S1029/zebrafish S815) previously shown to be phosphorylated by CaMKII.

PMIDs: 30458707