CAMK4

Phenotypes

Mouse phenotype:

enlarged heart, abnormal heart morphology, abnormal testis morphology, enlarged testis

Subcellular localization

motile cilia, Nucleoplasm, Nucleoli fibrillar center, Endoplasmic reticulum

References: PMID:39743588

Function

We identify two additional RS-tethered protein kinases (CAMK4 and STKLD1) (Fig. 3). CAMK4, a member of the calcium/calmodulin-dependent protein kinase family, is bound to both RS1 and RS2, in which it nestles into a pocket surrounded by RSPH1, DYDC2 and PPIL6 (Extended Data Fig. 7d). Density resembling an ADP molecule can be resolved in the nucleotide-binding pocket of both copies of RS-associated CAMK4, suggesting that the kinase is active (Supplementary Fig. 14)(39743588). Identified by cryo-EM as a component of radial spokes 1 and 2 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).