CAMSAP1

calmodulin regulated spectrin associated protein 1

Ensembl:
ENSG00000130559
UniProt:
Q5T5Y3
OMIM:
613774
Synonyms:
DKFZP434F195, FLJ31228

Cilia effects upon perturbation of CAMSAP1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating phosphate level, preweaning lethality, complete penetrance, increased grip strength

Subcellular localization

cilia, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration

Function

Wdr47 facilitates proper neurite remodeling through Camsaps to fine-tune regional microtubule dynamics and organization during early stages of neuronal polarization(32320668). Camsap1, Camsap2, and Camsap3 colocalize with Wdr47 in multicilia (34608154).