CAMSAP2

calmodulin regulated spectrin associated protein family member 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000118200
UniProt:
Q08AD1
OMIM:
613775
Synonyms:
CAMSAP1L1, KIAA1078

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.63) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, microtubules, basal body

References: PMID:41005307, PMID:32320668, PMID:34608154

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration

Function

Wdr47 facilitates proper neurite remodeling through Camsaps to fine-tune regional microtubule dynamics and organization during early stages of neuronal polarization(32320668). Camsap1, Camsap2, and Camsap3 colocalize with Wdr47 in multicilia (34608154).