CANX

Cilia effects upon perturbation of CANX

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.64) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=973, lfc=-2.03) PMID:30270045

Phenotypes

Mouse phenotype:

abnormal thymus morphology, preweaning lethality, incomplete penetrance, enlarged thymus, enlarged uterus, abnormal spleen morphology, no spontaneous movement, enlarged spleen, abnormal skeletal muscle morphology

Mouse ciliopathy phenotype:

enlarged heart, abnormal uterus morphology, abnormal heart morphology

Subcellular localization

cilia, endoplasmic reticulum

Functional category

• Ciliary assembly/disassembly
• Viral interactions
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

A Wnt/beta-catenin pathway antagonist chibby binds cenexin at the distal end of mother centrioles and functions in primary cilia formation. Cby interacted with one of the appendage components, Cenexin (Cnx), which thereby abrogated the inhibitory effect of Cby on β-catenin-mediated transcriptional activation in a dose-dependent manner. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx(22911743).