CAPN6

calpain 6

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000077274
OMIM:: 300146
Synonyms:: CALPM, CANPX, CAPNX

Subcellular localization

Vesicles, Centriolar satellite

References: PMID:31619317

Functional category

Signaling (Hedgehog
GPCRs
ion channels)
Ciliary assembly/disassembly

Function

calpain-6 was selected as a positive regulator of ciliogenesis. We found that calpain-6 deficiency reduced the percentage of ciliated cells and impaired sonic hedgehog signaling. It has been speculated that this defect might be associated with decreased levels of α-tubulin acetylation at lysine 40. This is the first study to report a novel role of calpain-6 in the formation of primary cilia[31619317].

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