CASP2

caspase 2

Ensembl:
ENSG00000106144
UniProt:
P42575
OMIM:
600639
Synonyms:
ICH1, MGC2181, NEDD2, PPP1R57

Cilia effects upon perturbation of CASP2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged cecum, abnormal skin morphology, increased brain size, increased startle reflex, abnormal cecum morphology
Mouse ciliopathy phenotype:
abnormal reti morphology, abnormal brain morphology, enlarged testis, cataract, abnormal vitreous body morphology, persistence of hyaloid vascular system, abnormal testis morphology, abnormal kidney morphology, small kidney

Subcellular localization

basal body, cytosol, nucleus, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Transition zone
  • Transcription regulation

Function

CASP2 has localized in basal body, transition zone.