CASP2

caspase 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000106144
UniProt:
P42575
OMIM:
600639
Synonyms:
ICH1, MGC2181, NEDD2, PPP1R57

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged cecum, abnormal skin morphology, increased brain size, increased startle reflex, abnormal cecum morphology

Subcellular localization

basal body, cytosol, nucleus, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Transition zone
  • Transcription regulation

Function

CASP2 has localized in basal body, transition zone.