CASP8

caspase 8

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000064012
UniProt:
Q14790
OMIM:
601763
Synonyms:
CASP-8, FLICE, MACH, MCH5

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.16) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=705, lfc=-1.57) PMID:30270045

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance, embryonic lethality prior to tooth bud stage, increased heart left ventricle size, small liver

Subcellular localization

autophagosomes, cytosol, endosome, flagella, microtubules, mitochondria, nucleus

References: PMID:25613900

Functional category

  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CASP8 has localized in flagella.