CATIP

ciliogenesis associated TTC17 interacting protein

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000158428
UniProt:: Q7Z7H3
OMIM:: 619387
Synonyms:: C2ORF62, MGC50811

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased mean platelet volume

Subcellular localization

flagella, nucleus

References: PMID:41410385, PMID:42010243, PMID:24475127, PMID:39743588

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

It is involved in primary ciliogenesis in human cells and modulates actin polymerization, its depletion reduces the number of primary cilia without changing their length, suggesting it would be involved in cilia initiation rather than in cilia elongation. C2orf62 in association with TTC17 probably act on both motile and primary cilia formation (PMID: 24475127). Identified by cryo-EM as a component of radial spoke 3 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.