CATIP

Cilia effects upon perturbation of CATIP

Ciliogenesis screen results (1 screen)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased mean platelet volume

Mouse ciliopathy phenotype:

male infertility

Subcellular localization

flagella, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

It is involved in primary ciliogenesis in human cells and modulates actin polymerization, its depletion reduces the number of primary cilia without changing their length, suggesting it would be involved in cilia initiation rather than in cilia elongation. C2orf62 in association with TTC17 probably act on both motile and primary cilia formation (PMID: 24475127).