CATSPER1

cation channel sperm associated 1

Ensembl:
ENSG00000175294
UniProt:
Q8NEC5
OMIM:
606389
Synonyms:
CATSPER

Cilia effects upon perturbation of CATSPER1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.03) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CatSper is thus vital to cAMP-mediated Ca2+ influx in sperm, sperm motility and fertilization (11595941).