CATSPER2

cation channel sperm associated 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000166762
UniProt:
Q96P56
OMIM:
607249

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.62) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella, cilia

References: PMID:41005307, PMID:11595941

Functional category

  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CatSper is thus vital to cAMP-mediated Ca2+ influx in sperm, sperm motility and fertilization (11595941).