CATSPER2
cation channel sperm associated 2
- Ensembl:
- ENSG00000166762
- UniProt:
- Q96P56
- OMIM:
- 607249
Cilia effects upon perturbation of CATSPER2
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.62) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse ciliopathy phenotype:
- male infertility
Subcellular localization
flagella
Functional category
- Actin & cytoskeleton regulation
- T cell biology
- Reproduction & sperm
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
Function
CatSper is thus vital to cAMP-mediated Ca2+ influx in sperm, sperm motility and fertilization (11595941).
Model organism evidence
Mus musculus (2 references)
Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum.
In sperm from CatSper1 or CatSper2 null mice, which lack functional flagellar alkaline-activated calcium currents, 50 microM thimerosal raised the flagellar bend amplitudes from abnormally low levels to normal pre-hyperactivated levels and, in 20-40% of sperm, induced hyperactivation.