CATSPER3

cation channel sperm associated 3

Ensembl:
ENSG00000152705
UniProt:
Q86XQ3
OMIM:
609120
Synonyms:
CACRC

Cilia effects upon perturbation of CATSPER3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.59) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased pulmory ventilation, abnormal eye morphology
Mouse ciliopathy phenotype:
male infertility, abnormal adrel gland morphology, enlarged adrel glands

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CatSper3 and CatSper4 Are Specifically Expressed in Testis and Sperm (17227845)

Model organism evidence

Mus musculus (1 reference)

Results: We showed that CatSper is present in the sperm flagella of C.

PMIDs: 38020915