CATSPER4

cation channel sperm associated 4

Ensembl:
ENSG00000188782
UniProt:
Q7RTX7
OMIM:
609121

Cilia effects upon perturbation of CATSPER4

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.05) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CatSper3 and CatSper4 Are Specifically Expressed in Testis and Sperm (17227845)

Model organism evidence

Mus musculus (2 references)

A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking.

PMIDs: 37725640, 36993167